Hippocampal long-term potentiation (LTP) is widely believed to be a cellular substrate for learning and memory. A likely physiological stimulus for initiating LTP is repetitive neuronal activity, which also results in K + accumulation extracellularly . Therefore, the involvement of elevated extracel
Induction of hippocampal long-term potentiation in the absence of extracellular Ca2+
โ Scribed by P. B. Y. May; J. W. Goh; Dr. B. R. Sastry
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 643 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0887-4476
No coin nor oath required. For personal study only.
โฆ Synopsis
Extracellular Ca2+, synaptic transmission, and the activation of subsynaptic receptors are not required for the induction of long-term potentiation of excitatory synaptic transmission at stratum radiatum-CAI neuron junctions as long as sufficient depolarizations of the presynaptic terminals and the postsynaptic neurons co-occur.
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