Induction of hepatic apolipoprotein B mRNA editing for reducing serum cholesterol levels: A breakthrough or a disaster

✍ Scribed by J Greeve; J R Chowdhury; N R Chowdhury

• Book ID: 102241106
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 185 KB
• Volume: 24
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.510240436

✦ Synopsis

INDUCTION OF HEPATIC APOLIPOPROTEIN B mRNA

coronary artery disease. 2 The intestine, the second major source of triglyceride-rich lipoproteins, secretes chylomi-EDITING FOR REDUCING SERUM CHOLESTEROL LEVELS: A BREAKTHROUGH OR A DISASTER? crons, which contain apo B-48 as the core protein. 2 Unlike VLDL, chylomicrons are rapidly and completely cleared by Yamanaka S, Balestra ME, Ferrell LD, Fan J, Arnold KS, the liver after triglyceride hydrolysis, without giving rise to Taylor S, Taylor JM, et al. Apolipoprotein B mRNA-editing long-lived apo B-containing lipoproteins. 2 protein induces hepatocellular carcinoma and dysplasia in

The synthesis of apo B-48 is the result of mRNA editing, transgenic animals. Proc Natl Acad Sci U S A 1995;92:8483which consists of a specific base change from C to U in the 8487.

apo B mRNA, creating a premature stop codon. 3 The editing is mediated by the apo B-mRNA editing enzyme, which spe-