## Abstract The induction of heat shock proteins by heat shock is classically defined as the heat shock response, which is involved in cytoprotection, inflammation and immune responses. Whereas the cytoprotective properties of heat shock have been well characterized, the immunomodulating roles of t
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Induction of heat shock protein 72 synthesis by endogenous tumor necrosis factor via enhancement of the heat shock element-binding activity of heat shock factor 1
β Scribed by Naoki Watanabe; Naoki Tsuji; Shinichiro Akiyama; Hiroyoshi Sasaki; Tetsuro Okamoto; Daisuke Kobayashi; Tsutomu Sato; Tsukasa Hagino; Naofumi Yamauchi; Yoshiro Niitsu; Akira Nakai; Kazuhiro Nagata
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Volume
- 27
- Category
- Article
- ISSN
- 0014-2980
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Exposure of 9L rat brain tumor cells to 40-100 Β΅M CdCl 2 for 2 h leads to an induction of a wide spectrum of heat shock proteins (HSPs). We have demonstrated that induction of the 70-kDa HSP (HSP70) and enhanced expression of its cognate (HSC70) by cadmium are concentration dependent and that the in