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Induction of factor VIII-specific unresponsiveness by intrathymic factor VIII injection in murine hemophilia A

โœ Scribed by S. MADOIWA; T. YAMAUCHI; E. KOBAYASHI; Y. HAKAMATA; M. DOKAI; N. MAKINO; Y. KASHIWAKURA; A. ISHIWATA; T. OHMORI; J. MIMURO; Y. SAKATA


Book ID
109152869
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
659 KB
Volume
7
Category
Article
ISSN
1538-7933

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Factor VIII (FVIII) is a multidomain protein that is deficient in hemophilia A, a clinically important bleeding disorder. Replacement therapy using recombinant human FVIII (rFVIII) is the main therapy. However, approximately 15-30% of patients develop inhibitory antibodies that neutralize rFVIII act