𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Induction of epstein-barr virus early antigens by corticosteroids: Inhibition by TPA and retinoic acid

✍ Scribed by G. Bauer

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
493 KB
Volume
31
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Corticosteroids can induce the synthesis of EBV antigens in the Burkitt lymphoma line Daudi. As early as 12 h after application of the drug, an increase of EA‐positive cells can be seen, the maximum induction being reached after 2 days. Nanogram amounts per ml of hormone are sufficient for measurable effects. Early antigen induction by corticosteroids does not require replication of viral DNA. Induction by corticosteroid differs from induction by other systems in two major respects: (1) it does not cooperate with other inducers, and (2) it is specifically inhibited by 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA). Induction by corticosteroids, however, shares at least one retinoic acid‐sensitive step with induction by chemicals such as TPA, 5‐iodo‐2‐deoxyuridine (IdUrd), n‐butyric acid (n‐BA) or inducing serum factor. This study defines three qualitatively different effects of TPA in Daudi cells: an inhibitory effect on EBV induction by corticosteroids and two differential types of synergistic effects with serum factor or n‐BA, respectively. In this particular cell line, TPA exhibits no inducing capacity when applied alone.

📜 SIMILAR VOLUMES

TPA induction of Epstein-Barr virus earl
TPA induction of Epstein-Barr virus early antigens in Raji cells is blocked by selective protein kinase-C inhibitors
✍ Janis Lazdins; Claudia Zompetta; Settimio Grimaldi; Giuseppe Barile; Marco Venan 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 494 KB 👁 1 views

We have shown that modulation of intracellular calcium in EBV latently infected cells could induce the expression of viral antigens, and suggested that a protein kinase-C (PKC) may play a major role in the EBV genome activation. We now report further investigations on the role of PKC using 2 selecti

Induction of epstein-barr virus by a new
Induction of epstein-barr virus by a new tumor promoter, teleocidin, compared to induction by TPA
✍ Hidehiko Yamamoto; Takato Katsuki; Yorio Hinuma; Hiro-O Hoshino; Masanao Miwa; H 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 424 KB 👁 1 views

## Abstract The effect of teleocidin, a new, naturally occurring tumor promoter, on induction of Epstein‐Barr virus (EBV), was compared with that of a known tumor promoter, 12‐__O__‐tetradecanoyl‐phorbol‐13‐acetate (TPA). Early antigen (EA) and/or capsid antigen (VCA) of EBV was induced in the EBV

Differential inhibition of epstein-barr
Differential inhibition of epstein-barr virus induction by the amino acid analogue, L-canavanine
✍ Naoki Yamamoto; Nikolaus Mueller-Lantzsch; Harald Zur Hausen 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 463 KB 👁 1 views

## Abstract The effect of an amino acid analogue, L‐canavanine, on the synthesis of Epstein‐Barr virus (EBV) antigens was investigated in lymphoblastoid cells. The analysis revealed that after infection of BJAB and NC‐37 cells with P3HR‐I EBV synthesis of early antigen (EA) was not affected by cana

Induction of epstein-barr virus antigens
Induction of epstein-barr virus antigens by tumor promoters for epidermal and nonepidermal tissues
✍ Kenzo Takada; Harald Zur Hausen 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 494 KB 👁 1 views

## Abstract Fifteen established tumor promoters belonging to different chemical groups were tested for their ability to induce Epstein‐Barr virus (EBV)‐specific early antigens (EA) in EBV‐genome‐positive nonproducer Raji cells. Saccharin (a promoter in urinary bladder carcinogenesis), DDT (a promot

Detection of epstein-barr virus early an
Detection of epstein-barr virus early antigen-d and its antibodies by passive hemagglutination
✍ Clifton A. Ogburn; Barbara Ann Zajac 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 French ⚖ 815 KB

## Abstract These data describe the use of a passive hemagglutination test (PHAT) for the detection of antibodies to the Epstein‐Barr virus (EBV) associated antigen, early antigen‐D (EA‐D). EA‐D was obtained from EBV‐superinfected RPMI 64–10 cell preparations which showed by immunofluorescent stain

Early events in transformation of human
Early events in transformation of human cord leukocytes by epstein-barr virus: Induction of dna synthesis, mitosis and the virus-associated nuclear antigen synthesis
✍ Takao Aya; Toyoro Osato 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 543 KB

## Abstract The present investigations were undertaken to establish the early events in EBV‐induced transformation of human cord lymphocytes with particular reference to the induction of DNA synthesis, mitosis and viral synthesis. When cord leukocytes were exposed to a 3 h pulse of^2^H‐TdR at 3 h i