## Members of the transforming growth factor-โค superfamily, including bone morphogenetic protein 4 (BMP-4), have been implicated as regulators of neuronal and glial differentiation. To test for a possible role of BMP-4 in early mammalian neural specification, we examined its effect on neurogenesis
โฆ LIBER โฆ
Induction of epidermis and inhibition of neural fate by Bmp-4
โ Scribed by Wilson, Paul A.; Hemmati-Brivanlou, Ali
- Book ID
- 109793586
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 890 KB
- Volume
- 376
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/376331a0
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## Background The molecular mechanism that initiates the formation of the vertebrate central nervous system has long been debated. Studies in __Xenopus__ and mouse demonstrate that inhibition of BMP signaling is sufficient to induce neural tissue in explants or ES cells respectively, whereas studie