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Induction of Endothelial Cell Apoptosis by Solid Tumor Cells

✍ Scribed by Florence Kebers; Jean-Marc Lewalle; Joëlle Desreux; Carine Munaut; Laetitia Devy; Jean-Michel Foidart; Agnès Noël

Book ID
115602920
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
323 KB
Volume
240
Category
Article
ISSN
0014-4827

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The anti-tumor drug Flavopiridol is a potent inhibitor of cyclin-dependent kinases (cdks). As a consequence, Flavopiridol-treated cells arrest in both G1 and G2, but Flavopiridol has also been shown to be cytotoxic for some tumor cell lines. The underlying molecular events are, however, unclear. We