Induction of effective antitumor immune responses in a mouse bladder tumor model by using DNA of an α antigen from mycobacteria

Induction of effective antitumor immunit

Induction of effective antitumor immunity in a mouse brain tumor model using B7-1 (CD80) and intercellular adhesive molecule 1 (ICAM-1; CD54) transfection and recombinant interleukin 12

✍ Tatsuhiro Joki; Tetsuro Kikuchi; Yasuharu Akasaki; Saburo Saitoh; Toshiaki Abe; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 139 KB 👁 2 views

Although tumor-specific T lymphocytes recognize tumorassociated antigens (TAA) present on their cell surface via major histocompatibility complex (MHC) molecules, T cells require other activating signals. These are provided by costimulatory molecules, including B7-1 (CD80), B7-2 (CD86) and intercell