Induction of Drug Resistance in Human Rhabdomyosarcoma Cell Lines Is Associated with Increased Maturation: Possible Explanation for Differentiation in Recurrences?

Overexpression of interleukin-2 receptor

Overexpression of interleukin-2 receptor α in a human squamous cell carcinoma of the head and neck cell line is associated with increased proliferation, drug resistance, and transforming ability

✍ Deborah J. Kuhn; David M. Smith; Seth Pross; Theresa L. Whiteside; Q. Ping Dou 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB 👁 1 views

## Abstract It has been previously demonstrated that human carcinomas express interleukin‐2 receptor (IL‐2R) α, β, and γ chains. The β and γ chains of IL‐2R have intermediate binding affinity for IL‐2 and are responsible for the intracellular signaling cascades after IL‐2 stimulation. IL‐2Rα lacks