## Abstract The effect of hepatocyte growth factor/scatter factor (HGF/SF) on the proliferation of human skin fibroblasts was examined. At concentrations above 1.0 ng/ml, both native and recombinant human HGF/SF stimulated the DNA synthesis determined by [^3^H]thymidine incorporation, which was com
Induction of DNA synthesis and cell division in human diploid skin fibroblasts by fibroblast growth factor
β Scribed by Daphne Kamely; P.S. Rudland
- Book ID
- 118877015
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- English
- Weight
- 544 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0014-4827
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## Abstract The effects of fresh human serum (FHS) and heatβinactivated human serum (HHS) on the DNA synthesis and proliferation of human diploid fibroblasts were assessed. FHS activated significantly more quiescent fibroblasts to undergo DNA synthesis and proliferation than did HHS. The stimulator
In vitro exposure of normal human diploid fibroblasts (strain VH-10) to ethylene oxide (EtO) induced DNA strand breaks in the dose range of 2.5-30 mMh of EtO. Alkaline DNA unwinding (ADU), neutral filter elution (NFE), pulsed field gel electrophoresis (PFGE), and the comet assay were used to measure