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Induction of cytotoxic T cells as a novel independent survival factor in malignant melanoma with percutaneous peptide immunization

โœ Scribed by Fujiyama, Toshiharu; Oze, Isao; Yagi, Hiroaki; Hashizume, Hideo; Matsuo, Keitaro; Hino, Ryosuke; Kamo, Riei; Imayama, Shuhei; Hirakawa, Satoshi; Ito, Taisuke; Takigawa, Masahiro; Tokura, Yoshiki

Book ID
122168962
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
907 KB
Volume
75
Category
Article
ISSN
0923-1811

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The human melanocyte lineage-specific antigen gp100 contains several epitopes recognized by cytotoxic T lymphocytes (CTL). However, most of the epitopes reported to date are HLA-A2.1-restricted. Despite the high frequency of HLA-A2.1 in melanoma patients, effective population coverage requires the i