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Induction of cytolytic T lymphocytes against pediatric solid tumors in vitro using autologous dendritic cells pulsed with necrotic primary tumor

✍ Scribed by Joel Shilyansky; Paulette Jacobs; Kara Doffek; Sonia L. Sugg

Book ID: 116686125
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 266 KB
Volume: 42
Category: Article
ISSN: 0022-3468
DOI: 10.1016/j.jpedsurg.2006.09.008

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## BACKGROUND. Most strategies in cancer immunotherapy are aimed at the induction of a strong cellular immune response against the tumor. Particularly, CD8 + T lymphocytes have been proven in multiple animal models to be critical for the eradication of solid tumors. METHODS. We used a population o