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Induction of cyclooxygenase and nitric oxide synthase in endotoxin-activated J774 macrophages is differentially regulated by indomethacin: Enhanced cyclooxygenase-2 protein expression but reduction of inducible nitric oxide synthase

✍ Scribed by Linhua Pang; J.Robin S. Hoult

Book ID: 117098853
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 524 KB
Volume: 317
Category: Article
ISSN: 0014-2999
DOI: 10.1016/s0014-2999(96)00703-0

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## Abstract Recent studies suggest AMP‐activated protein kinase (AMPK), an enzyme involved in energy homeostasis, might be a novel signaling pathway in regulating inflammatory response, but the precise intracellular mechanisms are not fully understood. In this study, we have demonstrated that 5‐ami