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Induction of cyclooxygenase-2 in reactive glial cells by the CD40 pathway: relevance to amyotrophic lateral sclerosis

✍ Scribed by Tatsusada Okuno; Yuji Nakatsuji; Atsushi Kumanogoh; Ken Koguchi; Masayuki Moriya; Harutoshi Fujimura; Hitoshi Kikutani; Saburo Sakoda


Book ID
111178503
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
286 KB
Volume
91
Category
Article
ISSN
0022-3042

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## Abstract A glial reaction associated with up‐regulation of inflammatory molecules has been suggested to play an important role in dopaminergic neuron loss in Parkinson's disease (PD). Among inflammatory molecules, inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) have been focu