𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Induction of CTGF by TGF-β1 in osteoblasts: Independent effects of Src and Erk on Smad signaling

✍ Scribed by Xuemei Zhang; John A. Arnott; Saqib Rehman; William G. DeLong; Archana Sanjay; Fayez F. Safadi; Steven N. Popoff


Book ID
116320924
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
65 KB
Volume
43
Category
Article
ISSN
8756-3282

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Src is a major signaling component for C
✍ X. Zhang; J.A. Arnott; S. Rehman; W.G. DeLong Jr; A. Sanjay; F.F. Safadi; S.N. P 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 321 KB

## Abstract Connective tissue growth factor (CTGF/CCN2) is induced by transforming growth factor β1 (TGF‐β1) where it acts as a downstream mediator of TGF‐β1 induced matrix production in osteoblasts. We have shown the requirement of Src, Erk, and Smad signaling for CTGF induction by TGF‐β1 in osteo

TGF-β1-induced Smad 3 binding to the Sma
✍ Kenneth R. Cutroneo; Sem H. Phan 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB

## Abstract Bleomycin produces its fibrogenic effect, at least in part, by TGF‐β1 secretion. Treatment of IMR‐90 human embryonic lung fibroblasts with bleomycin at 0.5 μg/ml results in a 1.6‐fold increase of TGF‐β1 as determined by a specific ELISA assay for TGF‐β1 after acidification of the condit

Role of Smad3, acting independently of t
✍ Yoshifumi Inoue; Lucie Canaff; Geoffrey N. Hendy; Itoko Hisa; Toshitsugu Sugimot 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 344 KB 👁 1 views

## Abstract Parathyroid hormone (PTH) exerts an anabolic action on bone but the mechanisms are incompletely understood. We showed previously that PTH interacts with the canonical Wnt‐β‐catenin signaling pathway via the transforming growth factor (TGF)‐β signaling molecule, Smad3, to modulate osteob

Induction of an epithelial to mesenchyma
✍ Maria Davies; Max Robinson; Emily Smith; Suzy Huntley; Stephen Prime; Ian Paters 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 511 KB

## Abstract Recent data indicate that transforming growth factor‐β1 (TGF‐β1) can act to promote tumour progression in the late stages of carcinogenesis. The mechanism by which this occurs is unknown although a ligand‐induced epithelial–mesenchymal transition (EMT) is thought to be important. In thi