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Induction of complete remission in a patient with acute myeloid leukemia refractory to high-dose chemotherapy through treatment with 5-azacytidine

✍ Scribed by A. Kuendgen; T. Gräf; F. Zohren; B. Hildebrandt; A. Hünerlitürkoglu; N. Gattermann; R. Haas; G. Kobbe

Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
654 KB
Volume
31
Category
Article
ISSN
0145-2126

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✦ Synopsis

For patients with acute myeloid leukemia refractory to intensive chemotherapy prognosis is very poor and treatment options are limited. 5-Azacytidine, a demethylating drug, is effective in the treatment of myelodysplastic syndromes when administered at a low-dose, subcutaneously. We report a case of a patient with AML refractory to induction chemotherapy as well as to two high-dose salvage regimens. The patient achieved CR through monotherapy with low-dose azacytidine.

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✍ Joseph M. Brandwein; Vikas Gupta; Andre C. Schuh; Aaron D. Schimmer; Karen Yee; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB 👁 2 views

## Abstract Eighty‐one patients with acute myeloid leukemia who had persistent leukemia following standard induction therapy with cytarabine plus daunorubicin (7+3 regimen) underwent reinduction therapy with a combination of mitoxantrone, etoposide, and high‐dose cytarabine (HiDAC). Patients achiev