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Induction of colon tumors by a single oral dose of 1,2-dimethylhydrazine

โœ Scribed by Schiller, Carol M.; Curley, Winifred H.; McConnell, Ernest E.


Book ID
122849721
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
301 KB
Volume
11
Category
Article
ISSN
0304-3835

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โœ Cihangir Celik; David A. Lewis; Arnold Mittleman ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 284 KB

Although carly studies in germ-free rats showed almost complete dependence on dimethylhydrazine (DMH) colon carcinogenesis upon the presence of colon bacteria, no adequate explanation was givcn for the 20% tumor incidence observed in germ-free animals. Bacterial activation of liver microsomal produc