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Induction of cMrp/cMoat gene expression by cisplatin, 2- acetylaminofluorene, or cycloheximide in rat hepatocytes

โœ Scribed by H Kauffmann; D Keppler; J Kartenbeck; D Schrenk


Book ID
118686707
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
636 KB
Volume
26
Category
Article
ISSN
0270-9139

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Induction of cMrp/cMoat gene expression
โœ H Kauffmann; D Keppler; J Kartenbeck; D Schrenk ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 638 KB

The human multidrug-resistance-associated protein (MRP), a member of the adenosine triphosphate (ATP)-binding cassette transporter superfamily, is frequently overexpressed in tumor cells resistant to antineoplastic drugs. In the rat, two Mrp isoforms have been identified, Mrp and cMrp. cMrp, also ca