Induction of chromosome aberrations by fusarium T-2 toxin in cultured human peripheral blood lymphocytes and Chinese hamster fibroblasts

✍ Scribed by Chu-Chieh Hsia; Van Gao; Jiang-Li Wu; Bao-Lang Tzian

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 742 KB
• Volume: 129
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1041290413

✦ Synopsis

is an important representative of trichothecenes produced by various species of imperfect fungi, mainly Fusarium genus. It is a naturally occurring toxin that can cause severe diseases in human and animals. No definite data demonstrating the carcinogenic potential of T-2 toxin had been reported up to now. We demonstrated that 1-2 toxin reproducibly induced chromosomal structural aberrations both in cultured human peripheral blood lymphocytes as well as in V79 Chinese hamster fibroblasts. The mean percentage of cells with aberration of human lymphocytes from normal individuals induced by T-2 toxin is 49-fold (9.8%) of the mean percentage of corresponding control cultures without T-2 toxin (0.2%). T-2 toxin induced chromosome type (76%) as well as chromatid type (24%) of aberrations; among them, acentric fragment (46%) was the most common type, and chromatid gap, deletion, and chromosome gap were the next most common.