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Induction of cell cycle arrest in human MCF-7 breast cancer cells by cis-stilbene derivatives related to VIOXX®

✍ Scribed by Sunisa Sangjun; Esther de Jong; Sandra Nijmeijer; Thumnoon Mutarapat; Somsak Ruchirawat; Martin van den Berg; Majorie B.M. van Duursen

Book ID
119380814
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
854 KB
Volume
186
Category
Article
ISSN
0378-4274

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✍ Józefa Węsierska-Gądek; Margarita Maurer; Gerald Schmid 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 253 KB 👁 1 views

## Abstract We reported recently that roscovitine (ROSC), a selective cyclin‐dependent kinase (CDK) inhibitor, arrests human MCF‐7 breast cancer cells in G~2~ phase of the cell cycle, and concomitantly induces apoptosis. Human MCF‐7 breast cancer cells are known to express elevated levels of c‐Ha‐R