The anti-tumor drug Flavopiridol is a potent inhibitor of cyclin-dependent kinases (cdks). As a consequence, Flavopiridol-treated cells arrest in both G1 and G2, but Flavopiridol has also been shown to be cytotoxic for some tumor cell lines. The underlying molecular events are, however, unclear. We
✦ LIBER ✦
Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells
✍ Scribed by Friesen, Claudia; Fulda, Simone; Debatin, Klaus-Michael
- Book ID
- 110015910
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 194 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1350-9047
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## Abstract Salvicine, a novel topoisomerase II inhibitor and a diterpenoid quinone compound, exerts potent __in vitro__ and __in vivo__ antitumor effects. In our study, we show that salvicine effectively kills multidrug‐resistant (MDR) sublines, such as K562/A02, KB/VCR and MCF‐7/ADR, and parental