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Induction of caspase-8 in human cells by the extracellular administration of peptides containing a C-terminal SLV sequence

✍ Scribed by Anne Scheller; Matthias Melzig; Johannes Oehlke


Book ID
110327309
Publisher
Springer Netherlands
Year
2001
Tongue
English
Weight
102 KB
Volume
8
Category
Article
ISSN
1573-3149

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## Abstract A p53 C‐terminal peptide (aa 361–382, p53p), fused at its C‐terminus to the minimal carrier peptide of __antennapedia__ (17 aa, Ant; p53p‐Ant), induced rapid apoptosis in human cancer cells, __via__ activation of the Fas pathway. We examined p53p‐Ant mechanism of action, toxicity in var