Induction of arthritis in SCID mice by T cells specific for the “shared epitope” sequence in the G3 domain of human cartilage proteoglycan

Induction of arthritis in HLA–DR4–humani

Induction of arthritis in HLA–DR4–humanized and HLA–DQ8–humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background

✍ Sándor Szántó; Tamás Bárdos; Zoltán Szabó; Chella S. David; Edit I. Buzás; Katal 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 391 KB

## Abstract ## Objective To determine whether the rheumatoid arthritis (RA)–predisposing class II molecules of the major histocompatibility complex (MHC) can present cartilage proteoglycan (PG) aggrecan, and if so, to determine the epitope repertoire of the human cartilage PG in HLA‐transgenic mic