Hormonal breast cancer therapies have traditionally been considered cytostatic, but recent pre-clinical data suggest that anti-oestrogens can induce apoptosis. The aim of this study was to assess whether tamoxifen (TAM) and ICI 182780 (ICI) could induce apoptosis in human breast cancer, and whether
Induction of apoptosis in mammary gland by a pure anti-estrogen ICI 182780
โ Scribed by K.B. Lim; C.Y. Ng; C.K. Ong; C.S. Ong; E. Tran; T.T.T. Nguyen; G.M.T.W. Chan; H. Huynh
- Book ID
- 110305480
- Publisher
- Springer US
- Year
- 2001
- Tongue
- English
- Weight
- 350 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0167-6806
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Both primary and acquired resistance to the growthinhibitory effects of anti-estrogens (e.g.. tamoxifen) limits the clinical usefulness of these drugs in the treatment of breast cancer. The new, steroidal anti-estrogen ICI 182.780 was tested for its ability to inhibit the proliferation of a tamoxife
We have compared the effects of a broad range of clinically relevant concentrations (0.1 to 10 M) of the steroidal pure anti-estrogen ICI 182,780 and the non-steroidal partial antiestrogen tamoxifen (TAM) on cell proliferation and induction of apoptosis in the estrogen receptor (ER)-negative ovarian