Retinoids are promising agents for the prevention and treatment of several human malignancies including lung cancer. However, many lung cancer cell lines are resistant to the growth inhibitory effects of all-trans-retinoic acid (ATRA). Recently, we found that a new synthetic retinoid, 6-[3-(1-adaman
โฆ LIBER โฆ
Induction of Apoptosis in Human Pancreatic Carcinoma Cells by a Synthetic Bleomycin-like Ligand
โ Scribed by Suginaka, Rei ;Izui, Reiko ;Inoue, Jun-ichiro ;Muraoka, Yasuhiko ;Yamaguchi, Ken ;Otsuka, Masami ;Umezawa, Kazuo
- Book ID
- 108581624
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1998
- Tongue
- English
- Weight
- 399 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0910-5050
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We have examined the ability of gamma-irradiation and bleomycin to induce apoptosis in a model system consisting of cell lines derived from naturally occurring human head-and-neck squamous-cell carcinomas with contrasting p53 status and expression levels of pro- and anti-apoptotic molecules. Followi