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Induction of Apoptosis in Cerebellar Granule Cells by 2,4-Dichlorophenoxyacetic Acid

✍ Scribed by K. L. De Moliner; A. M. Evangelista de Duffard; E. Soto; R. Duffard; A. M. Adamo

Book ID
110410077
Publisher
Springer
Year
2002
Tongue
English
Weight
383 KB
Volume
27
Category
Article
ISSN
0364-3190

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Caspase-3 activity increased dramatically in cytosolic extracts of rat cerebellar granule cells exposed to apoptotic conditions (basal medium Eagle (BME) containing 5 mM K Ψ‰ without serum) when assayed with Ac-DEVD-amc, but not with Ac-YVAD-afc, a preferred substrate for caspase-1. This provided a b