## Abstract Recent data indicate that transforming growth factor‐β1 (TGF‐β1) can act to promote tumour progression in the late stages of carcinogenesis. The mechanism by which this occurs is unknown although a ligand‐induced epithelial–mesenchymal transition (EMT) is thought to be important. In thi
Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-β in human normal lung epithelial cells
✍ Scribed by Yanagisawa, Kiyoshi; Osada, Hirotaka; Masuda, Akira; Kondo, Masashi; Saito, Toshiko; Yatabe, Yasushi; Takagi, Kenzo; Takahashi, Toshitada; Takahashi, Takashi
- Book ID
- 110061534
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 361 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract TGF‐β signaling is indispensible for development of the nervous system since it regulates ontogenetic cell death. The recently identified TGF‐β‐inducible zinc finger protein Tieg3/Klf11 belongs to the family of Sp1/Klf‐like transcription factors and shares all structural and functional
## Abstract Platelet derived growth factors (PDGF) are known to be associated with vitreoretinal disorders such as proliferative vitreoretinopathy (PVR). We have studied the expression of PDGF and their receptors in human retinal pigment epithelial cells (HRPE) and choroid fibroblasts (HCHF), and t
## Abstract The net balance between urokinase‐type plasminogen activator (uPA) and plasminogen activator inhibitor type‐1 (PAI‐1) has been implicated in tumor cell invasion and metastasis. To elucidate the mechanism of the transforming growth factor‐β1 (TGF‐β1)‐dependent up‐regulation of PAI‐1 expr
Retinoids regulate the growth and differentiation of human tracheobronchial epithelial cells. In this study, we investigated the effects of all-trans-retinoic acid (trans-RA) and receptor class-selective retinoids on the growth and apoptosis of human lung cancer cell lines. Trans-RA significantly in