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Induction of Apoptosis by Shikonin through Coordinative Modulation of the Bcl-2 Family, p27, and p53, Release of Cytochrome c , and Sequential Activation of Caspases in Human Colorectal Carcinoma Cells

✍ Scribed by Hsu, Ping-Chi; Huang, Yu-Ting; Tsai, Mei-Ling; Wang, Ying-Jan; Lin, Jen-Kun; Pan, Min-Hsiung

Book ID: 127300912
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 279 KB
Volume: 52
Category: Article
ISSN: 0021-8561
DOI: 10.1021/jf0495993

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## Abstract A p53 C‐terminal peptide (aa 361–382, p53p), fused at its C‐terminus to the minimal carrier peptide of __antennapedia__ (17 aa, Ant; p53p‐Ant), induced rapid apoptosis in human cancer cells, __via__ activation of the Fas pathway. We examined p53p‐Ant mechanism of action, toxicity in var