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Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53

✍ Scribed by Sabine Grösch; Karin Schilling; Astrid Janssen; Thorsten J. Maier; Ellen Niederberger; Gerd Geisslinger

Book ID
113487471
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
409 KB
Volume
69
Category
Article
ISSN
0006-2952

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## Abstract Stress protein mortalin (mtHSP70) is highly expressed in cancer cells. It was shown to contribute to carcinogenesis by sequestrating the wild type p53, a key tumor suppressor protein, in the cytoplasm resulting in an abrogation of its transcriptional activation function. We have found t