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Induction of apoptosis by plumbagin through reactive oxygen species-mediated inhibition of topoisomerase II

✍ Scribed by Anna Kawiak; Jacek Piosik; Grzegorz Stasilojc; Anna Gwizdek-Wisniewska; Lukasz Marczak; Maciej Stobiecki; Jacek Bigda; Ewa Lojkowska

Book ID
113924159
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
791 KB
Volume
223
Category
Article
ISSN
0041-008X

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## Abstract Sphingosylphosphorylcholine (SPC) produces reactive oxygen species (ROS) in MS1 pancreatic islet endothelial cells. In the present study, we explored the physiological significance of the SPC‐induced ROS generation in endothelial cells. SPC induced cell death of MS1 cells at higher than