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Induction of apoptosis by A3 adenosine receptor agonist N6-(3-iodobenzyl)-adenosine-5′-N-methylcarboxamide in human leukaemia cells: a possible involvement of intracellular mechanism

✍ Scribed by P. Mlejnek; P. Dolezel


Book ID
111383978
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
416 KB
Volume
199
Category
Article
ISSN
1748-1708

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P-glycoprotein mediates resistance to A3
✍ Petr Mlejnek; Petr Dolezel; Petr Kosztyu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 514 KB

## Abstract We studied effects of 2‐chloro‐N^6^‐(3‐iodobenzyl)‐adenosine‐5′‐N‐methyluronamide (Cl‐IB‐MECA) on apoptosis induction in the K562/Dox cell line, which overexpressed P‐glycoprotein (P‐gp, __ABCB1__, __MDR1__). We found that the K562/Dox cell line was significantly more resistant to Cl‐IB