P-glycoprotein mediates resistance to A3
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Petr Mlejnek; Petr Dolezel; Petr Kosztyu
📂
Article
📅
2011
🏛
John Wiley and Sons
🌐
English
⚖ 514 KB
## Abstract We studied effects of 2‐chloro‐N^6^‐(3‐iodobenzyl)‐adenosine‐5′‐N‐methyluronamide (Cl‐IB‐MECA) on apoptosis induction in the K562/Dox cell line, which overexpressed P‐glycoprotein (P‐gp, __ABCB1__, __MDR1__). We found that the K562/Dox cell line was significantly more resistant to Cl‐IB