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Induction of apoptosis and tissue factor (TF) expression in germ cell tumor cell lines by cisplatin chemotherapy

✍ Scribed by C. Jacobsen; B. Spath; C. Bokemeyer; K. Oechsle; F. Honecker; F. Langer

Book ID
117258548
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
70 KB
Volume
129
Category
Article
ISSN
0049-3848

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We investigated the role of p53 and of the Bcl-2 family proteins in the apoptotic response of a panel of testicular tumour cell lines (NT2, NCCIT, S2 and 2102 EP). The p53 gene status and the capacity of the p53 protein to transactivate the p21/WAF/CIP gene were determined, and we examined the corre