## Abstract Our study was designed to investigate the role of the anti‐apoptotic proteins Bcl‐2 and Bcl‐xL in the chemoresistance of cells derived from malignant pleural mesothelioma. First, we determined the basal expression levels of Bcl‐2 and Bcl‐xL in mesothelioma cells and examined the effect
Induction of apoptosis and chemosensitization of mesothelioma cells by Bcl-2 and Bcl-xL antisense treatment
✍ Scribed by S Hopkins-Donaldson; R Cathomas; AP Simões-Wüst; S Kurtz; L Belyanskya; RA Stahel; U Zangemeister-Wittke
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- French
- Weight
- 28 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The original article to which this Erratum refers was published in International Journal of Cancer (2003) 106(2) 160–166
📜 SIMILAR VOLUMES
Over-expression of the anti-apoptotic protein bcl-xL is frequently found in lung cancer where it potentially contributes to tumor development, progression and drug resistance. To override the apoptotic block in lung-adenocarcinoma and small-cell-lung-cancer (SCLC) cells caused by over-expression of
Pancreatic cancer is one of the leading causes of cancerrelated death in Western countries. Bcl-x L is an anti-apoptotic factor of the Bcl-2 family, which is overexpressed in pancreatic cancer and its presence correlates with shorter patient survival. In this study, sequence-specific antisense oligo
## Background: Inhibition of apoptosis, or programmed cell death, may be critical both in the development of cancer and in determining response to therapy. the authors examined the expression of two related apoptotic inhibitors, bcl-2 and bcl-xl, in pretreatment biopsies from a series of 42 patient