Induction of anti-inflammatory immune response by an adenovirus vector encoding 11 tandem repeats of Aβ1–6: Toward safer and effective vaccines against Alzheimer’s disease

Nasal inoculation of an adenovirus vecto

Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Aβ1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's disease

✍ Hong-Duck Kim; Kazuki Tahara; J. Adam Maxwell; Robert Lalonde; Tatsuya Fukuiwa; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 394 KB

Background One of the pathological hallmarks of Alzheimer's disease (AD) is deposits of amyloid β-peptide (Aβ) in neuritic plaques and cerebral vessels. Immunization of AD mouse models with Aβ reduces Aβ deposits and improves memory and learning deficits. Because recent clinical trials of immunizati