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Induction of an immune response to benzo[A]pyrene by a benzo[a]pyrene protein conjugate synthesized in the cytochrome P-450 system

✍ Scribed by N. V. Shipulina; N. Yu. Tomilina; I. E. Kovalev; V. A. Tomilin


Book ID
112400229
Publisher
Springer
Year
1989
Tongue
English
Weight
434 KB
Volume
23
Category
Article
ISSN
0091-150X

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## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino