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Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells

โœ Scribed by Abe, K.; St. George-Hyslop, P.H.; Tanzi, R.E.; Kogure, K.


Book ID
122473357
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
279 KB
Volume
125
Category
Article
ISSN
0304-3940

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One of the pathological lesions in Alzheimer's disease (AD) is the amyloid or senile plaque. The plaque core is predominantly made up of amyloid beta peptide (AP), a 42-43 amino acid peptide derived from amyloid precursor protein (APP). APP is a membrane bound glycoprotein which is expressed ubiquit