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Induction of acyl-coenzyme A synthetase (ACS) gene expression by fibrates is mediated by a PPAR-responsive element in the 1C promoter of the ACS gene

✍ Scribed by K. Schoonjans; B. Staels; T. Yamamoto; W. Wahli; P. Grimaldi; J. Auwerx


Book ID
118325107
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
157 KB
Volume
109
Category
Article
ISSN
0021-9150

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Production of the glycoprotein hormone ␣-subunit (GPH␣) was enhanced by sodium butyrate (Btr) in HeLa cells. Induction of the HeLa ␣-subunit gene by Btr was inhibited by the simultaneous addition of cycloheximide (CHX), indicating a requirement for continued protein synthesis. Transient expression a