The natural-killer(NK)-cell-mediated cytotoxicity to syngeneic tumor cells can be augmented by in vivo priming and subsequent in vitro challenge with the streptococcal preparation OK432. Supernatants of cocultures of spleen cells with OK432 contained interleukin-2 (IL-2) and interferon (IFN), mainly
โฆ LIBER โฆ
Induction of activated natural killer cells from murine spleen cells primed in vivo and subsequently challenged in vitro with the streptococcal preparation OK432
โ Scribed by Hiroki Yamaue; Masaharu Katsumi; Katsuyoshi Tabuse; Yoji Tabuse; Koichi Kuribayashi; Toru Nishihara; Koji Saito
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 636 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0340-7004
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The in vivo anti-tumor activity of 2 recombinant cytokines, interleukin-2 (rlL-2) and human hybrid interferon alpha (rHulFN-aA/D), were tested using the murine reticulum cell sarcoma M5076. Experimental hepatic metastases, following i.v. injection of tumor cells, and tumor growth and spontaneous met