Induction of a lymphotoxin-like mediator in peripheral blood and synovial fluid lymphocytes by incubation with synovial fluid from patients with rheumatoid arthritis
β Scribed by G. R. Burmester; P. Beck; R. Eife; H. H. Peter; J. R. Kalden
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 431 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0172-8172
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Rheumatoid arthritis is a T cell-mediated autoimmune disease. The lack of knowledge of the involved target antigens severely hampers research on relevant T cells in patients. Here we describe the functional analysis of freshly isolated T cells from the peripheral blood and the site of the lesion (sy
Polymorphonuclear leukocytes (PM Ns) isolated from peripheral blood and synovial fluid o f patients with rheumatoid arthritis and from peripheral blood o f volunteers were stimulated with 12-phorbol-13-myristate acetate (PMA). No significant differences in luminol-amplified chemiluminescence were fo
## Abstract Suppressor/cytotoxic T cells express the surface marker CD8, which can be measured in a soluble form in culture supernatants of activated human lymphocytes. Using a sandwich immunoassay, we assessed the levels of soluble CD8 (sCD8) in serum from patients with rheumatoid arthritis (RA; n