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Induction and suppression of renal and hepatic cytochrome P450-dependent monooxygenases by acute and chronic streptozotocin diabetes in hamsters

โœ Scribed by T. L. Chen; S. H. Chen; T. Y. Tai; C. C. Chao; S. S. Park; F. P. Guengerich; T. H. Ueng


Publisher
Springer-Verlag
Year
1996
Tongue
English
Weight
936 KB
Volume
70
Category
Article
ISSN
0340-5761

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The effects of long-term insulin-dependent diabetes on the enzymatic activities of hepatic cytochrome P450 isozymes were determined in rats rendered diabetic by the administration of streptozotocin and killed 4, 8, and 12 weeks following treatment. The 0-dealkylations of ethoxyresorufin and pentoxyr