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Induction and Maintenance of Differentiation of Rat Lens Epithelium by FGF-2, Insulin and IGF-1

โœ Scribed by ERIK JAN KLOK; NICOLETTE H LUBSEN; CORAL G CHAMBERLAIN; JOHN W McAVOY


Book ID
115605294
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
646 KB
Volume
67
Category
Article
ISSN
0014-4835

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## Abstract Dโ€type cyclins are direct targets of extracellular signals and critical regulators of G~1~ progression. Our previous data demonstrated that IGFโ€I and FGFโ€2 synergize to enhance cyclin D1 expression, cyclin E/cdk2 complex activation, and Sโ€phase entry in OP cells. Here, we provide a mech