Induction and alternative splicing of the Bax gene mediated by p53 in a transformed endothelial cell line
β Scribed by S. A. Maxwell; S. A. Acosta; G. E. Davis
- Book ID
- 110277226
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 900 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1360-8185
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Codon 273 is one of the hot spots of missense mutation of the p53 tumor suppressor gene found in human cancers. We have previously reported that a mutation at codon 273, p53-273L (Arg 3 Leu), suppresses cell growth despite its having no p53-specific transactivation activity. To further elucidate the