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Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat

✍ Scribed by Silva, Renata; Sousa, Emília; Carmo, Helena; Palmeira, Andreia; Barbosa, Daniel José; Gameiro, Mariline; Pinto, Madalena; Lourdes Bastos, Maria; Remião, Fernando


Book ID
121565747
Publisher
Springer-Verlag
Year
2014
Tongue
English
Weight
811 KB
Volume
88
Category
Article
ISSN
0340-5761

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✍ Ana I. Alvarez; Rebeca Real; Miriam Pérez; Gracia Mendoza; Julio G. Prieto; Grac 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 266 KB

The present article aims to review the up-to-date information on the most recent studies of the interaction of flavonoids with ABC transporters, in particular the drug pharmacokinetic consequences of such a relationship. In addition, the modulation of the expression of the ABC transporters by flavon