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Inducing a change in the pharmacokinetics and biodistribution of poly-l-lysine in rats by complexation with heparin

โœ Scribed by Thomas P. Johnston; Kamesh R. Kuchimanchi; Hemant Alur; Montakarn Chittchang; Ashim K. Mitra


Book ID
111768839
Publisher
Pharmaceutical Press
Year
2003
Tongue
English
Weight
323 KB
Volume
55
Category
Article
ISSN
2042-7158

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## Abstract Nonenzymatic glycation of macromolecules, especially proteins, takes place mainly due to hyperglycemia in diabetes mellitus. Increased glycolysis during cancer and inflammation during rheumatoid arthritis also contribute to the process of glycation. As lysine residues of proteins are a