Inducible nitric oxide synthase promotes cytokine expression in cardiac allografts but is not required for efficient rejection

BH4 (tetrahydrobiopterin)-dependent acti

BH4 (tetrahydrobiopterin)-dependent activation, but not the expression, of inducible NOS (nitric oxide synthase)-2 in proinflammatory cytokine-stimulated, cultured normal human astrocytes is mediated by MEK–ERK kinases

✍ Anna Chiarini; Ilaria Dal Pra; Rossella Gottardo; Federica Bortolotti; James F. 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 321 KB 👁 2 views

## Abstract Nitric oxide (NO) from astrocytes is one of the signalers used by the brain's extensive glial‐neuronal‐vascular network, but its excessive production by pro‐inflammatory cytokine‐stimulated glial cells can be cytodestructive. Here, we show how three pro‐inflammatory cytokines (IL‐1β, TN