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Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damage

โœ Scribed by Kenneth E Hill; Lauren V Zollinger; Hilary E Watt; Noel G Carlson; John W Rose

Book ID
113729298
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
825 KB
Volume
151
Category
Article
ISSN
0165-5728

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Nitric oxide synthase is present in the
Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels
โœ Vittorio Calabrese; Giovanni Scapagnini; Agrippino Ravagna; Rita Bella; Roberta ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 196 KB ๐Ÿ‘ 2 views

Nitric oxide (NO) is hypothesized to play a role in the immunopathogenesis of multiple sclerosis (MS). Increased levels of NO metabolites have been found in patients with MS. Peroxynitrite, generated by the reaction of NO with superoxide at sites of inflammation, is a strong oxidant capable of damag