Inducible nitric oxide synthase gene expression in the brain during systemic inflammation
β Scribed by Wong, Ma-Li; Rettori, Valeria; AL-Shekhlee, Amer; Bongiorno, Peter B.; Canteros, Griselda; McCann, Samuel M.; Gold, Philip W.; Licinio, Julio
- Book ID
- 109928556
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 624 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1078-8956
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This study, based on in situ hybridization and immunolabeling experiments, presents the time-course and cellular distribution of inducible NO synthase (iNOS) expression in a rat model of brain inflammation. Both intrahippocampal injection of lipopolysaccharide (LPS) or of buffer (stab lesion) induce
## Abstract Although the inducible isoform of nitric oxide synthase (iNOS) is a wellβestablished source of nitric oxide (NO^β’^) during inflammation of the central nervous system (CNS), little is known about the involvement of constitutive isoforms of NOS (cNOS) in the inflammatory process. The aim