Inducible model to study negative strand RNA synthesis and assembly of hepatitis C virus from a full-length cDNA clone

Small interfering RNA effectively inhibi

Small interfering RNA effectively inhibits protein expression and negative strand RNA synthesis from a full-length hepatitis C virus clone

✍ Ramesh Prabhu; Padmaja Vittal; Qinyan Yin; Erik Flemington; Robert Garry; Willia 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 242 KB 👁 1 views

## Abstract Hepatitis C virus (HCV) infection is usually treated with the combination of interferon and ribavirin, but only a small fraction of patients develop a sustained remission. There is need for the development of specific molecular approaches for the treatment of chronic HCV infection. We p