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Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

โœ Scribed by Brummer, T.


Book ID
111749990
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
378 KB
Volume
21
Category
Article
ISSN
0261-4189

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## Abstract cAMPโ€dependent, PKAโ€independent effects on cell proliferation are mediated by cAMP binding to EPAC and activation of Rap signaling. In this report, we employed the analogue 8โ€CPTโ€2โ€Oโ€Meโ€cAMP to study binding to EPAC and subsequent activation of Bโ€Raf/ERK and mTOR signaling in human canc