Epac1-induced cellular proliferation in
โ
Uma Kant Misra; Salvatore Vincent Pizzo
๐
Article
๐
2009
๐
John Wiley and Sons
๐
English
โ 524 KB
## Abstract cAMPโdependent, PKAโindependent effects on cell proliferation are mediated by cAMP binding to EPAC and activation of Rap signaling. In this report, we employed the analogue 8โCPTโ2โOโMeโcAMP to study binding to EPAC and subsequent activation of BโRaf/ERK and mTOR signaling in human canc