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Inducible expression of AML1-ETO fusion protein endows leukemic cells with susceptibility to extrinsic and intrinsic apoptosis

✍ Scribed by Lu, Y; Xu, Y-B; Yuan, T-T; Song, M-G; Lübbert, M; Fliegauf, M; Chen, G-Q


Book ID
110056737
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
220 KB
Volume
20
Category
Article
ISSN
0887-6924

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Leukemogenic AML1-ETO fusion protein upr
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## Abstract AML1‐ETO, a fusion protein generated by the chromosomal translocation t(8;21), is frequently associated with acute myeloid leukemia (AML). In addition to blocking differentiation, AML1‐ETO is also shown to induce growth arrest in AML cells, which is unfavorable for leukemogenesis harbor